Obefazimod
✓ Phase 3 complete
Abivax
Pill that boosts miR-124
Positive phase 3 trials in UC. Pre-filing meeting with the FDA was positive.
Filing in preparation
Autoimmune · inflammatory bowel disease
Crohn's and Ulcerative Colitis
Chronic gut inflammation. Many biologics exist, but many patients stop responding. The new anti-TL1A class may also tackle fibrosis.
- Cure
- None yet
- Current treatment
- Anti-inflammatories, immunosuppressants, biologics and surgery
- Who has it
- About 7 million people worldwide
- Updated
4candidates on the board
Phase 3 completefurthest phase
2updates in 2026
What changed
The latest developments, newest first.
ProgressObefazimod nears its approval filing
Abivax had a positive FDA meeting and is preparing the UC filing.
ProgressTulisokibart succeeds in phase 3
First phase 3 win for an anti-TL1A. A maintenance study is still needed before filing.
Treatments in development
Each column is a step on the road to the pharmacy. Colors show the type of treatment.
- Antibody or biologic (3)
- Oral drug (1)
Phase 3confirmation · 4
Tulisokibart
MSD (Merck)
Anti-TL1A antibody
First anti-TL1A to achieve remission in a UC phase 3. Crohn's phase 3 ongoing.
Result: Jun 2026
Duvakitug
Teva · Sanofi
Anti-TL1A antibody
Durable phase 2 effect in Crohn's and UC. Now in phase 3.
In phase 3
Afimkibart
Roche
Anti-TL1A antibody
Third anti-TL1A in final-stage testing.
In phase 3
Left behind
Candidates that looked promising and were stopped. Most treatments tested never reach the market.
Etrolizumabe
2022 · Roche stopped it after mixed phase 3 results.
Frequently asked questions
Is there a cure for Crohn's and Ulcerative Colitis?
None yet. Current treatment: Anti-inflammatories, immunosuppressants, biologics and surgery.
Which Crohn's and Ulcerative Colitis treatments are being tested?
Fasevia tracks 4 candidates: Obefazimod (Phase 3 complete); Tulisokibart (Phase 3); Duvakitug (Phase 3); Afimkibart (Phase 3).
What is the most advanced Crohn's and Ulcerative Colitis treatment in development?
The furthest along today is Obefazimod (Abivax), in phase 3 complete. Positive phase 3 trials in UC. Pre-filing meeting with the FDA was positive.
When could a new Crohn's and Ulcerative Colitis treatment arrive?
A drug has to complete phase 3 and be reviewed by health agencies such as the FDA or EMA, which usually takes several years. The leading candidate today is in phase 3 complete.