Ácido hialurônico
Vários centros
Injection around the plaque
Studied in stable disease as a gentler option than collagenase.
Review: 2026
Urology · penile fibrosis
Peyronie's Disease
An internal scar causes curvature and pain. Research is small and mostly academic; experts estimate 5 to 10 years to a new treatment. 2026's news comes from combining old drugs.
- Cure
- None yet
- Current treatment
- Collagenase injections, traction and surgery
- Who has it
- Studies estimate 3% to 9% of adult men
- Updated
4candidates on the board
Phase 2furthest phase
2updates in 2026
What changed
The latest developments, newest first.
ProgressReview flags the acute phase as a treatment window
Acting early, before the scar hardens, may be key for antifibrotics.
ProgressViagra plus tamoxifen reduce curvature
UK pilot study published in the Journal of Sexual Medicine. Authors call for a prospective trial.
Treatments in development
Each column is a step on the road to the pharmacy. Colors show the type of treatment.
- Antibody or biologic (1)
- Oral drug (2)
- Vaccine, device or other (1)
Phase 2efficacy and dose · 1
Lab / pilotearly research · 3
Tadalafila/sildenafila + tamoxifeno
Anglia Ruskin · UCLH
Antifibrotic combination
133 men in the acute phase: 43% improved curvature vs 15% untreated; pain nearly vanished. Needs a controlled trial.
Published: May 2026
Inibidores de PDE1/PDE4
Anglia Ruskin
Blocking fibrosis formation
Prevented cells from turning fibrotic in the lab.
Lab
Colagenase de kiwi
Pesquisadores no Canadá
Natural enzyme
Possible alternative with fewer side effects than current collagenase.
Lab
Left behind
Candidates that looked promising and were stopped. Most treatments tested never reach the market.
Vitamina E e outros orais
— · Urology guidelines advise against them for lack of proven benefit.
Frequently asked questions
Is there a cure for Peyronie's Disease?
None yet. Current treatment: Collagenase injections, traction and surgery.
Which Peyronie's Disease treatments are being tested?
Fasevia tracks 4 candidates: Ácido hialurônico (Phase 2); Tadalafila/sildenafila + tamoxifeno (Lab / pilot); Inibidores de PDE1/PDE4 (Lab / pilot); Colagenase de kiwi (Lab / pilot).
What is the most advanced Peyronie's Disease treatment in development?
The furthest along today is Ácido hialurônico (Vários centros), in phase 2. Studied in stable disease as a gentler option than collagenase.
When could a new Peyronie's Disease treatment arrive?
A drug has to complete phase 3 and be reviewed by health agencies such as the FDA or EMA, which usually takes several years. The leading candidate today is in phase 2.